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Created with Raphaël 2.1.0 14.02.2018 Formal examination (assignment of filing date) 05.03.2018 Preliminary examination 22.03.2018 Establishment of the national regular filing 02.01.2019 Substantive examination 31.05.2019 Publication of the decision of grant (B1) 30.11.2019 Completion of the opposition filing period 31.12.2019 Issuance of patent (C1) 14.02.2023 Valid until 31.10.2023 Publication of the decision of forfeiture, with the re-establishment right 03.07.2024 14.08.2024 Payment of maintenance and surcharge fees 14.02.2038 Patent expiration date

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(11)Number of the document4631
(21)Number of the applicationa 2018 0007
(22)Filing date of the application2018.02.14
 Date of filing the request for examination (de fond) 14.02.2018
(71)Name(s) of applicant(s), code of the countryINSTITUTUL DE CHIMIE, MD;
(72)Name(s) of inventor(s), code of the countryARICU Aculina, MD; KUCHKOVA Kaleria, MD; DUCA Gheorghe, MD; SECARA Elena, MD; BARBA Alic, MD; DRAGALIN Ion, MD; UNGUR Nicon, MD;
(73)Name(s) of owner(s), code of the countryINSTITUTUL DE CHIMIE, MD;
(54)Title of the invention N-carbamimidoyl-2-((8aS)-2,5,5,8a-tetramethyl-3,4,4a,5,6,7,8,8a-octahydronaphthalene-1-yl)acetamide compound with antiproliferative and cytotoxic properties
(13)Kind-of-document code
C1, BOPI 12/2019
B1, BOPI 05/2019
(51)International Patent Classification C07C 277/00 (2006.01); C07C 279/00 (2006.01); A61K 31/00 (2006.01); A61K 31/13 (2006.01); A61K 31/155 (2006.01);
(19)CountryMD
(45)Date of publication of patent granting decision:2019.05.31
(47)Date of issuance of patent2019.12.31
 Substantive examiner(s)GROSU Petru
 Payment for maintenance up to the date2023.02.14
 Date of patent termination2023.02.14
 Date of publication of the termination of patent, with the right of restoration2023.10.31
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